Mortal Shell 2 Healing Upgrades: All 21 Revered Gland & Synaptic Vessel Locations

What the two upgrade types do

Revered Gland: increases the number of healing items you can carry.
Synaptic Vessel: increases how much each healing use restores.

Current launch coverage reports 21 total upgrades: 11 Revered Glands and 10 Synaptic Vessels. Two are purchases from Merrick; the remaining 19 are route pickups, dungeon rewards, or boss rewards.

Merrick’s healing-upgrade stock in Marrow Keep

All 21 healing-upgrade locations

Use the nearest Beacon or named area as your route anchor. The numbering is a checklist order from current guide coverage, not a mandatory collection route.

#	Upgrade	Beacon / area	Location
1	Revered Gland	Marrow Keep	Buy from Merrick for 1,500 coin.
2	Synaptic Vessel	Marrow Keep	Buy from Merrick for 1,500 coin.
3	Synaptic Vessel	Stonebled Gate	South of the Beacon, beside the camp fire and boxes.
4	Revered Gland	Nocthean Gate	At the end of Thieves Retreat, north of the Beacon and one level down.
5	Revered Gland	Mushroom Village	Inside Holding Cells, entered through a well northwest of the Beacon.
6	Synaptic Vessel	Mushroom Village	North of Deserted Mine, on the east edge of the Trial Obelisk’s stone circle.
7	Synaptic Vessel	Outskirts of Nochte	South of the Beacon, inside the north interior of the upper castle area.
8	Revered Gland	One Legged Wolf	Pale Grisha reward at the end of Grisha Hunting Grounds, northwest past the ruins.
9	Revered Gland	Widow’s Overlook	South of the Beacon, beside a body near the western cliff edge.
10	Revered Gland	Citadel of Penance	Southeast of the Beacon, behind a breakable wooden wall in the southwestern outer-castle corner.
11	Synaptic Vessel	Citadel of Penance	Behind the gate opened by the button opposite Eredrim’s former position.
12	Synaptic Vessel	One Legged Wolf	Through the eastern jump into Temple of Vatra, right before the large staircase.
13	Synaptic Vessel	Sester’s Gate	At the far back wall near boxes, past the long bridge with the bell-shooting route.
14	Synaptic Vessel	Gate of Infinity	At the first bookshelf climb point, on the left as you enter.
15	Synaptic Vessel	Castigator’s Keep	South of the Beacon, in the central courtyard.
16	Revered Gland	Abbey Entrance	In the cave east of town, behind the door opened by destroying three glowing tombstones.
17	Synaptic Vessel	Abandoned Outpost	In the Slums, among tombstones north of the western church building.
18	Revered Gland	High Lord’s Courtyard	In the central long building on the south side of the outer courtyard, in front of a statue.
19	Revered Gland	Sunken Village	In the container down the hill behind you, after cleansing the Beacon.
20	Revered Gland	Prisoners’ Domain	Past the toppled statue, beyond the iron-maiden room.
21	Revered Gland	Sanguine Shoreline	In a cave along the main path after the first open area.

The gated pickups

Thieves Retreat — Nocthean Gate

From Nocthean Gate Beacon, head north and drop one level. Use the switch to open the dungeon route, then follow the invisible walkways. The suspended bodies are the reported visual landmarks for the route to the Revered Gland.

Holding Cells — Mushroom Village

From Mushroom Village Beacon, go northwest to the route that enters Holding Cells. Use Mether’s Breath on the corruption blocking the jump pad, enter through the well, and find the button behind the boxes to open the Revered Gland room.

Pale Grisha — One Legged Wolf

Reach Grisha Hunting Grounds northwest past the ruins from the One Legged Wolf area. The Revered Gland is the reported reward for defeating Pale Grisha.

Citadel of Penance

For the Revered Gland, go southeast of the Beacon to the southwestern outer-castle corner and break the wooden wall. For the Synaptic Vessel, find and press the button on the wall opposite Eredrim’s former position to open the nearby gate.

Abbey Entrance

Enter the cave east of town and destroy all three glowing tombstones. The door to the Revered Gland opens after the third tombstone.

Sunken Village

Cleanse the Sunken Village Beacon first. Then turn around, walk down the hill, and check the container behind you.

Prisoners’ Domain

Follow the main path to the giant statue. Destroy the pots at its base to topple it, then pass the iron-maiden room to reach the Revered Gland.

How to check whether you collected one

There is no reported collection counter for these upgrades. Fast-travel back to the named location: if the pickup is gone, it was collected. Your healing item should also show the result—more charges for a Revered Gland or greater restoration for a Synaptic Vessel.

LootMap separately reports a 15-marker “Healing Upgrades” layer and 12 “Devout’s Chalice” artifacts. Do not add those artifact chalices to this 21-item Gland/Vessel checklist; current coverage treats them as a different map-layer category.

Are healing upgrades missable?

Current launch coverage reports that none of the 21 are missable and that uncollected upgrades remain available during free roam after the final boss. Treat that as current guide reporting rather than a permanent guarantee for every future patch.

Common mistakes

Counting Devout’s Chalices as Revered Glands or Synaptic Vessels.
Forgetting the 1,500-coin Merrick purchases in Marrow Keep.
Entering Holding Cells without first clearing the corruption at the jump pad.
Leaving the Sunken Village route before cleansing its Beacon.
Missing the Citadel button because the Vessel is not behind the same wooden wall as the Gland.
Expecting a collection counter to track the 21 pickups.

What happens next

For the progression gates that unlock several of these routes, see the Ova guide. The New Game Plus guide explains why Revered Glands and Synaptic Vessels are reported to respawn in a later run.

Sources

AllThingsHow — Every Healing Upgrade Location (21 Total) — 21-item list, upgrade effects, route gates, Merrick prices, and post-boss availability, updated 2026-08-18.
LootMap — Healing Upgrades: All 15 Chalice Locations — separate 15-marker Healing Upgrades layer and Devout’s Chalice artifact distinction, build 24841087, updated 2026-08-21.